Michael Carrick is set to miss between four and six weeks after suffering an Achilles injury, Sky Sports understands.
The midfielder has been nursing the problem for some time, but managed to play ninety minutes in the 1-0 win over league leaders Arsenal at the weekend.
However, he has been forced to withdraw from the England squad along with teammate Danny Welbeck for the forthcoming friendlies against Chile and Germany, and will now miss a sizeable portion of the champions’ title challenge.
The 32 year old is set to sit out of the league games against former club Tottenham Hotspur, Everton and Newcastle United and the Champions League clashes with Bayer Leverkusen and Shakhtar Donetsk.
Meanwhile, he is on the verge of being offered a new two year deal at Old Trafford, which could see him see out the rest of his career with the club, according to Talksport.
During his time with United, he has won the Premier League five times, and was part of the squad that won the Champions League in 2008.
Carrick began his career with West Ham United, moving to Spurs in 2004 and then on to United for £18.6m in the summer of 2006.