Saturday’s game at Old Trafford sees table toppers Manchester United host Sunderland.
Sir Alex Ferguson’s side extended their lead at the league’s summit to six points with their last minute victory over neighbours Manchester City last time out.
The Red Devil’s will be without Johnny Evans and Anderson, but could welcome back Nemanja Vidic, Shinji Kagawa and Nani whilst Wayne Rooney is expected to recover from an illness in time to feature.
The England striker has four goals in his last two games, and is 4.5 (7/2) with Bet 365 to open the scoring, whilst top scorer Robin Van Persie is a 3.9 (29/10) shot with Bet Victor.
Most firms have a price of 1.2 (1/5) on offer for the home win, with 17.0 (16/1) available for an unlikely away victory. The draw is 7.0 (6/1) with Bet Victor.
The visitors go in to the game on the back of a 3-0 victory over Reading on Tuesday; a result which saw them climb to fifteenth place and go two points clear of the relegation zone.
Adam Johnson and Danny Rose, who went off during that midweek victory will miss the trip to Manchester along with Lee Cattermole and former United duo Wes Brown and Phil Bardsley.
Top scorer Steven Fletcher returned on Tuesday to score his seventh goal of the season, and is widely available at 13.0 (12/1) to get the first goal of the game, whilst Stephane Sessegnon is a 21.0 (20/1) shot with most bookmakers.